| Pair Name | Neobavaisoflavone, TNF-related apoptosis inducing ligand | ||
| Phytochemical Name | Neobavaisoflavone (PubChem CID: 5320053 ) | ||
| Anticancer drug Name | TNF-related apoptosis inducing ligand (PubChem CID: / ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Neobavaisoflavone, TNF-related apoptosis inducing ligand | |||
| Disease Info | [ICD-11: 2F7Z] | Glioma | Investigative | |
| Biological Phenomena | Induction-->Apoptosis | |||
| Gene Regulation | Up-regulation | Expression | BAX | hsa581 |
| Up-regulation | Cleavage | BID | hsa637 | |
| Up-regulation | Activity | CASP3 | hsa836 | |
| Up-regulation | Activity | CASP8 | hsa841 | |
| Up-regulation | Activity | CASP9 | hsa842 | |
| Up-regulation | Expression | TNFRSF10B | hsa8795 | |
| In Vitro Model | U-373MG ATCC | Astrocytoma | Homo sapiens (Human) | CVCL_2219 |
| Result | Taken together, our results suggest that NBIF reduces the resistance of cancer cells to TRAIL and that the combination of NBIF and TRAIL may be a new therapeutic strategy for treating TRAIL-resistant glioma cells. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Neobavaisoflavone sensitizes apoptosis via the inhibition of metastasis in TRAIL-resistant human glioma U373MG cells. Life Sci. 2014 Jan 30;95(2):101-7. doi: 10.1016/j.lfs.2013.10.035. | Click |
